Infinity Biosciences

Unlocking Longevity Through Stem Cell Reprogramming

AI-driven discovery of druggable targets to reverse stem cell aging directly in human tissues

200+ human datasets

1 Million single cell data analyzed

200+ human datasets

1 Million single cell data analyzed

15+ Years of longevity

Extending healthspan & Lifespan

15+ Years of longevity

Extending healthspan & Lifespan

12 Rejuvenation targets

In-vivo Stem cell and niche reprogramming

12 Rejuvenation targets

In-vivo Stem cell and niche reprogramming

  1. Problem

  2. Aging causes stem cell failure

    Declining stem cell function drives immune dysfunction, tissue degeneration, and impaired body functions

    Intrinsic changes:

    1. Accumulation of DNA damage 2. Epigenetic alterations 3. Mitochondrial dysfunction

    Intrinsic changes:

    1. Accumulation of DNA damage 2. Epigenetic alterations 3. Mitochondrial dysfunction

    Intrinsic changes:

    1. Accumulation of DNA damage 2. Epigenetic alterations 3. Mitochondrial dysfunction

    Extrinsic changes:

    1. Dysfunctional stem cell niches. 2. Altered systemic signaling (inflammatory cytokines, reduced growth factors).

    Extrinsic changes:

    1. Dysfunctional stem cell niches. 2. Altered systemic signaling (inflammatory cytokines, reduced growth factors).

    Extrinsic changes:

    1. Dysfunctional stem cell niches. 2. Altered systemic signaling (inflammatory cytokines, reduced growth factors).

    A flowing, abstract form with smooth, wavy textures is depicted, featuring a gradient of soft green and fiery orange hues, set against a muted brown background.

  3. Figure adapted from López-Otín et al., 2023, Cell. Used for illustrative purposes.

No therapies today restore aged stem cells in vivo

Restoring aged stem cells in their native environment remains an unmet challenge.

Our Solution

A Target-Based Approach to Rejuvenation

We discover molecular targets that restore stem cell function inside their native tissue environment.

We discover molecular targets that restore stem cell function inside their native tissue environment.

Pilot Study in Hematopoietic Stem Cells (HSC)

Our approach aims to restore function, reverse aging pathways, and preserve cell identity.

200+

healthy people aged 23 to 91 (male and female) analyzed

200+

healthy people aged 23 to 91 (male and female) analyzed

1M+

Single cell transcriptomes from HSC stem and niche cells

1M+

Single cell transcriptomes from HSC stem and niche cells

12

High confidence Rejuvenation targets identified

12

High confidence Rejuvenation targets identified

3 Classes

1.Transcriptional regulators 2.Metabolic pathway modulators 3.Niche signaling mediators

3 Classes

1.Transcriptional regulators 2.Metabolic pathway modulators 3.Niche signaling mediators

Why it matters?

Hematopoietic Stem Cells form blood and immune cells

Addressing a major unmet need in tackling aging and restoring whole-body health

Addressing a major unmet need in tackling aging and restoring whole-body health

Our mission

Over 80% of the cells in our body are blood and immune cells, produced in the bone marrow by hematopoietic stem cells (HSCs).
As we age, these stem cells lose their strength, weakening the immune system and increasing the risk of disease.

By rejuvenating HSCs and their surrounding environment (niche), we aim to address a large part of age-related decline and reduce the risk of serious conditions, including cancer.

Adapted from Zhang et al., 2019, Stem Cell Research & Therapy,

under Creative Commons CC BY 4.0 license.

Our goal is to rejuvenate all types of adult stem cells and their surrounding niche to restore the body’s natural regenerative capacity.

Join us in our mission to extend the healthspan and lifespan of people worldwide.